Biomolecular Modeler

Position Overview


Ailomics Therapeutics is seeking a talented Biomolecular Modeler to join our computational team to model protein-protein interactions, design antigens and antibodies. You will construct protein-protein complex structure models to understand biological signaling at the molecular level. You will design antigens for antibody identification as well as design mutagenesis libraries for antibody optimization. You have a track record of building protein homology models and predicting protein-protein complex structures. You have a passion in biology understanding and data-driven drug R&D, along with strong independent thinking, learning and innovating capabilities, communication skills and collaboration spirit.
 

 

Responsibilities


 Construct protein-protein complex structure models to understand biological signaling at the molecular level.
 Design antigens to enable identification of antibodies with target and epitope specificities.
 Design mutagenesis libraries to optimize antibody bioactivities and properties.
 Implement in silico tools in antibody discovery campaigns to ensure rapid and early selection of antibodies with optimal developability.
 Collaborate with Computational Biologists, Immunologists and Antibody Engineers to achieve the above goals.
 Have the opportunity to lead technology/platform development.
 Have the opportunity to lead drug projects.
 

 

Qualifications


 Ph.D. in Biomolecular Modeling or a relevant field.
 A track record of expertise in Biomolecular Modeling, evidenced through scientific publications and, if available, impacts on target validation and antibody discovery in the pharmaceutical industry.
 Demonstrated capabilities of building protein homology models and predicting protein-protein complex structures; experience in utilizing AI methods is highly desirable.
 Experience of antigen and antibody design is a big plus.
 Solid foundation in molecular dynamics simulations.
 Understanding of AI/deep learning techniques is a plus.
 Passion for biology understanding and data-driven drug R&D.
 Strong capabilities of independent thinking, learning and innovating.
 A team player with good communication skills in both English and Mandarin.

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